Specialty · Oncology

Neutropenic sepsis caught on the phone, not in the corridor.

Symptom monitoring between cycles, neutropenic sepsis thresholds applied to every contact, treatment preparation, and coordination across the teams a cancer patient is under at once.

< 20s
Fever on treatment to emergency advice
5.2x
More symptom checks between cycles
31%
Fewer unplanned admissions

In the product

Oncology monitoring — cycle 3, day 9

Emergency
  1. Outbound 19:40 · Margaret F. · 62 · FEC-T cycle 3 · expected nadir day 7–10

  2. Primum

    Have you taken your temperature today?

  3. Caller

    It was 38.3 about an hour ago. I felt shivery earlier but I've a blanket on now and I'm grand.

  4. Temp ≥ 38.0 on SACT within nadir → neutropenic sepsis pathway, immediate

  5. Primum

    I need you to go to hospital now — take your alert card and go straight to the acute oncology unit, not to a waiting room. Don't take paracetamol, it will mask things. Is there someone who can drive you?

  6. Caller

    My son is here.

  7. Primum

    Good. Leave now. I'm ringing the unit so they're expecting you.

Sepsis pathway

Regimen
FEC-T · cycle 3 of 6
Temperature
38.3°C
Day of cycle
9 · expected nadir
Rigors
Reported earlier
Pathway
Neutropenic sepsis
AOS
Notified 19:43

Patient en route · unit expecting · no antipyretic advised

A routine monitoring call becoming a sepsis pathway

Overview

Between cycles, the patient is at home and nobody is watching.

  • Any temperature on systemic therapy is an emergency pathway, not a question.
  • Toxicity graded against CTCAE and trended across cycles rather than recalled at clinic.
  • Appointments across oncology, imaging, surgery and palliative care coordinated for the patient.

The dangerous period in systemic anti-cancer therapy is the fortnight when the patient is not in the unit. Neutropenia peaks, toxicity develops, and the patient — who has been told not to be a nuisance — waits to see whether the temperature settles. Neutropenic sepsis kills people who felt well that morning.

Primum makes structured contact through that window: temperature, symptoms, toxicity grading against CTCAE, oral intake, adherence for oral agents. Any fever on treatment is treated as neutropenic sepsis until proven otherwise, with immediate instructions and the acute oncology service alerted. Everything else — treatment preparation, bloods, appointment coordination across teams — is handled so the patient is not the one holding it together.

Capabilities

What the fortnight between cycles needs

One threshold that must never be missed, and three programmes that keep treatment on track.

  • Fever is an emergency, full stop

    A temperature of 38°C or more, or rigors, or feeling unwell with a normal temperature while on treatment, produces immediate instructions to attend, the alert card referenced, and the acute oncology service notified — no triage delay, no call-back.

  • Toxicity graded and trended

    Mucositis, diarrhoea, neuropathy, rash, nausea, fatigue and hand-foot syndrome graded to CTCAE on every contact, so the oncologist sees a trajectory across cycles rather than a snapshot at clinic.

  • Oral therapy actually taken

    Adherence, timing and tolerability for oral agents, plus interaction checks against anything a different team has prescribed since the last cycle.

  • One diary across the teams

    Bloods, imaging, infusion, surgical review and palliative care coordinated in the right order, with preparation instructions for each — so the patient is not the one reconciling four appointment letters.

How it works

A cycle, watched the whole way through

Contact at the points where neutropenia and toxicity are known to peak.

  • Arrives
  • Decided
  • Done
  • Returned
  1. 01

    Cycle registered

    Regimen, cycle number, expected nadir and the patient's own risk factors loaded, with the contact schedule set from the protocol.

    Regimen-aware

  2. 02

    Symptoms taken

    Temperature, toxicity, oral intake and adherence captured at each contact, in the patient's own language, with follow-ups where an answer needs one.

    CTCAE graded

  3. 03

    Thresholds applied

    Neutropenic sepsis criteria checked first on every contact, then dose-limiting toxicity thresholds against your own tables.

    Sepsis criteria first

  4. 04

    Escalated or recorded

    Acute oncology alerted and the patient instructed to attend, or the graded record written back and the next cycle's bloods confirmed.

    AOS alert / write-back

Benefits

Earlier contact, fewer emergencies

Most unplanned oncology admissions are preceded by two days of symptoms nobody heard about.

  • Sepsis reaches hospital faster

    Door-to-antibiotic time is the measure that matters, and it starts when the patient decides to ring. Structured contact removes the decision.

  • Dose decisions have data

    Graded toxicity across the whole cycle, not the patient's recollection at clinic, is what makes a dose reduction the right size.

  • Patients stop coordinating their own care

    One diary across every team removes a burden that falls on people least able to carry it.

In practice

Four contacts in one cycle

The first is the reason the programme exists.

  • 38.3°C on day 9

    Emergency in 18s

    Fever during the expected nadir. Immediate instruction to attend with the alert card, and the acute oncology service notified before the call ends.

  • Grade 3 diarrhoea

    Same-day review

    Frequency crosses threshold with reduced oral intake. Escalated for assessment and hydration rather than managed at home.

  • Capecitabine, doses missed

    Reconciled

    Four doses missed after nausea. Adherence pattern recorded, antiemetic reviewed, oncologist informed before the next cycle.

  • Four letters, three teams

    Rebuilt in order

    Bloods, scan and infusion re-sequenced correctly, fasting instructions sent, and transport booked.

Start with the nadir window

Pick one regimen and let us run structured contact through days five to twelve. We will show you what was reported, how it was graded, and how many contacts produced an escalation nobody would otherwise have heard about.